team Senior B moves Brienon for 15h
appointment stage at 13:30
appointment stage at 13:30
Senior A team receives Neuvy Sautour for 15h
appointment stadium 14h
appointment stadium 14h
Saturday, March 5, 2011
Thursday, March 3, 2011
How To Get The Combination On Big Nate
Workouts Friday, March 4
Resumed workouts with regular hours:
19H30: Group SG2
21H00: group SG1 (RDV attention Friday to 20.30 for SG1 for a meeting with the coaches)
The girls found the room Duruy. 
Resumed workouts with regular hours:
19H30: Group SG2
21H00: group SG1 (RDV attention Friday to 20.30 for SG1 for a meeting with the coaches)
The girls found the room Duruy.
Honda Team Skierniewice
WE Games 5 and 6 March
Girls are still on vacation.
Two trips for boys:
team 1 plays Saturday night at 8:15 p.m. at Villeneuve de Marsan at the beginning of a series of five games away (4 in the league and cup 1in Landes). This Saturday should allow us to leave in a positive momentum after the failure in France Cup So many serious players will be asked.
The 2 plays a derby on Sunday morning at 11:00 AM in ST PIERRE DU MONT. He must win to avoid falling behind in the standings and keep the chances of catching VIGNAU THE leader of the hen.
The two victories are well within the string of Mons and the aim of the weekend. 
Girls are still on vacation.
Two trips for boys:
team 1 plays Saturday night at 8:15 p.m. at Villeneuve de Marsan at the beginning of a series of five games away (4 in the league and cup 1in Landes). This Saturday should allow us to leave in a positive momentum after the failure in France Cup So many serious players will be asked.
The two victories are well within the string of Mons and the aim of the weekend.
The Symptoms Of The Black Death In Order
When the game is a therapeutic tool
Using video games to deal with emotional conflicts and somatic alterations is not new. By cons, as games like this, serious games, are specially designed to be part of a psychological treatment is much more original, if not unique if more game interacts with the emotions of the patient recorded by sensors.
This innovation was developed in the framework of a European project called PlayMancer which brought together for 3 years from November 2007 to November 2010, eight partners from six different countries including Spain [1]. Each partner has had its role, that of the English partner, Bellvitge Hospital in Barcelona and its units responsible for eating disorders and pathological gambling, was in this case to define the scenarios that the game had to offer to perform its function therapy.
Since last September, the video game is now used regularly validated by the hospital. To its designers, the main objective of this tool original treatment is to teach its users to control their impulses and respond by demonstrating self-control and serenity in the face of stressful situations and frustration, typical manifestations of eating disorders and gambling addiction.
The main objective of the proposed scenario is to get out of an island. The data collected by sensors that detect facial expressions and voice as well as physiological reactions of the patient, can change the course of the game is only coming to check that the patient can "win the game" .
A preliminary study involving 30 patients and 30 control individuals showed that in accordance with the expectations of researchers, patients had improved behavior through play But to definitively proven, it must have been tested longer and more patient. So one solution: "Start again"!
For more information, contact:
[1] Website of the European project PlayMancer: http://www.playmancer.eu/
Source:
- Reference [1]
the brief - the press release dated February 7, 2011 Idibell Foundation Hospital Bellvitge
- La Vanguardia of February 8, 2011 
This innovation was developed in the framework of a European project called PlayMancer which brought together for 3 years from November 2007 to November 2010, eight partners from six different countries including Spain [1]. Each partner has had its role, that of the English partner, Bellvitge Hospital in Barcelona and its units responsible for eating disorders and pathological gambling, was in this case to define the scenarios that the game had to offer to perform its function therapy.
Since last September, the video game is now used regularly validated by the hospital. To its designers, the main objective of this tool original treatment is to teach its users to control their impulses and respond by demonstrating self-control and serenity in the face of stressful situations and frustration, typical manifestations of eating disorders and gambling addiction.
The main objective of the proposed scenario is to get out of an island. The data collected by sensors that detect facial expressions and voice as well as physiological reactions of the patient, can change the course of the game is only coming to check that the patient can "win the game" .
A preliminary study involving 30 patients and 30 control individuals showed that in accordance with the expectations of researchers, patients had improved behavior through play But to definitively proven, it must have been tested longer and more patient. So one solution: "Start again"!
For more information, contact:
[1] Website of the European project PlayMancer: http://www.playmancer.eu/
Source:
- Reference [1]
the brief - the press release dated February 7, 2011 Idibell Foundation Hospital Bellvitge
- La Vanguardia of February 8, 2011
Wednesday, March 2, 2011
Cv Sample Beauticion -
Here are 2 links to a few lines that trace the last Sunday in local newspapers St Yrieix perch.
It speaks of our supporters ...
Cup in France to Villa Handball Sport
http://www.lepopulaire.fr/sports/tous/handball_resultats_de_la_coupe_de_france_departementale_secteur_sud_ouest @ CARGNjFdJSsBExsACh0-.html
Modifying Tundra 2 Skidoo
experimental therapeutic vaccine against AIDS
Nearly 30 years that we have identified suspicious cases of pneumonia in the gay community in San Francisco without a name yet, AIDS began to be talked about.
If since 1996, the cocktails of antiviral drugs have proved successful in reducing to undetectable levels of the virus and have AIDS, at least in Western countries, chronic illness, the hope has long conjured a preventive vaccine, has so far backfired. It's still not a preventive vaccine is talking about a new scientific work, but a therapeutic vaccine which, however, opens interesting perspectives. This is a work primarily directed at Barcelona (13 of 17 researchers, 3 of the 4 others being INSERM-Université Pierre et Marie Curie, Hopital Pitie-Salpetriere in Paris) and involves two clutches AIDS in the Catalan capital, teachers Clotet (IrsiCaixa) and Gatell (Hivacat).
This work appeared in the Journal of Infectious Diseases [1] and available online, reports the results obtained during a Phase I clinical trial on people with HIV: 24 weeks after the first of three injections, vaccinated patients showed an enhanced immune response viral load and three times lower than the control group. This decline which the authors define as modest, has remained at least 48 weeks.
This vaccine is actually a vaccine tailored: from the blood of each patient, researchers have recovered part of the AIDS virus they were inactivated by heating and other dendritic cells (the immune system cells). They then grew the cells in contact with the virus to their "learn" to attack the virus. It is these cells that were injected into each patient. This strategy is not new and is being attempted in other research groups around the world but what is new in this work are the positive results were obtained.
Feasible, safe and well tolerated, to use the adjectives used by researchers in their paper, this strategy is therefore hopeful even though the side "to measure" will always be a limitation. The idea is, if future trials sanctioned the therapeutic approach would be to treat a patient with antivirals and vaccine to maintain without the aid of drugs, viral load very low. This is the meaning of new tests that are ongoing and which researchers believe have results within a year. Continued ...
For more information, contact:
[1] "A Dendritic Cell-Based Therapeutic Vaccine for HIV-1 Infection" by Felipe Garcia et al., Published in J Infect Dis. (2011) 203 [4] 473-478. doi: 10.1093/infdis/jiq077
- The scientific article in question
- El Pais on February 2, 2011
- La Vanguardia of February 2, 2011
Editor: Guy
Molénat, scientific attaché, service. scientifique@sst-bcn.com 
If since 1996, the cocktails of antiviral drugs have proved successful in reducing to undetectable levels of the virus and have AIDS, at least in Western countries, chronic illness, the hope has long conjured a preventive vaccine, has so far backfired. It's still not a preventive vaccine is talking about a new scientific work, but a therapeutic vaccine which, however, opens interesting perspectives. This is a work primarily directed at Barcelona (13 of 17 researchers, 3 of the 4 others being INSERM-Université Pierre et Marie Curie, Hopital Pitie-Salpetriere in Paris) and involves two clutches AIDS in the Catalan capital, teachers Clotet (IrsiCaixa) and Gatell (Hivacat).
This work appeared in the Journal of Infectious Diseases [1] and available online, reports the results obtained during a Phase I clinical trial on people with HIV: 24 weeks after the first of three injections, vaccinated patients showed an enhanced immune response viral load and three times lower than the control group. This decline which the authors define as modest, has remained at least 48 weeks.
This vaccine is actually a vaccine tailored: from the blood of each patient, researchers have recovered part of the AIDS virus they were inactivated by heating and other dendritic cells (the immune system cells). They then grew the cells in contact with the virus to their "learn" to attack the virus. It is these cells that were injected into each patient. This strategy is not new and is being attempted in other research groups around the world but what is new in this work are the positive results were obtained.
Feasible, safe and well tolerated, to use the adjectives used by researchers in their paper, this strategy is therefore hopeful even though the side "to measure" will always be a limitation. The idea is, if future trials sanctioned the therapeutic approach would be to treat a patient with antivirals and vaccine to maintain without the aid of drugs, viral load very low. This is the meaning of new tests that are ongoing and which researchers believe have results within a year. Continued ...
For more information, contact:
[1] "A Dendritic Cell-Based Therapeutic Vaccine for HIV-1 Infection" by Felipe Garcia et al., Published in J Infect Dis. (2011) 203 [4] 473-478. doi: 10.1093/infdis/jiq077
- The scientific article in question
- El Pais on February 2, 2011
- La Vanguardia of February 2, 2011
Editor: Guy
Molénat, scientific attaché, service. scientifique@sst-bcn.com
Cervical Mucus Before Period, Mucus
spontaneous mesosigmoid hematoma: a rare complication of oral anticoagulants throughout
If bleeding GI, induced by anticoagulants are frequent, intramural hematomas and mesenteric are rarer and their topography is preferred proximal duodenum, jejunum and above. The locations colic, especially sigmoid, are exceptional [1].
MSM, 43 years, chronic hemodialysis for five years, carrying a mechanical prosthetic mitral past three years and on long term anticoagulant therapy (Coumadin 4 mg / day) was admitted in March 2005 at the emergency department for pelvic pain lasting for a week, which had worsened, and generalized throughout the abdomen in a few hours with the appearance of syncope.
The examination revealed a state of shock with systolic blood pressure 70 mm Hg and a diastolic of 50 mmHg, profuse sweating, cold extremities and a significant mucocutaneous pallor. Abdominal palpation a tender mass in the left iliac fossa, ill-defined and mobile associated with distention and tenderness of the rest of the abdomen with dullness Slope.
The DRE revealed an melaena. Laboratory tests showed microcytic hypochromic anemia at 6 g / dl of hemoglobin and prothrombin time to 35% with an INR of 2.5. Abdominal ultrasound showed a peritoneal effusion of great abundance and a sigmoid wall thickening with anechoic halo périsigmoïdien.
urgent laparotomy was decided after a brief resuscitation and showed an abundance of hemoperitoneum and a hematoma of the sigmoid cracked and extended to the wall of the sigmoid (Fig. 1). Resection with double stoma was performed (Fig. 2). The postoperative course was uneventful. The restoration of gastrointestinal continuity was performed two months later. Examination histological part of colectomy showed the presence of a hemorrhagic collection at the mesocolon, which was leaking into the colonic subserosa, causing a detachment of the serosa. Elsewhere, there was a very congested in the mucosa and submucosa compared with no other associated injury, particularly vascular.
intramural hematomas can occur throughout the digestive tract. Trauma, hemophilia and anticoagulant therapy are the main causes. Cases of spontaneous hematomas were also reported
[2]. The most common are those located at of the small intestine and duodenum [3,4]. Hematoma of the colon and particularly those induced by anticoagulant therapy are very exceptional. Twelve cases are reported in the literature with only four locations sigmoid [1]. In association with bleeding and intraparietal intramésentérique may appear intraluminal bleeding, intra-or retroperitoneal [4].
abdominal pain and intestinal obstruction in general partial, are common symptoms. The INR is often increased beyond the therapeutic ranges. However, anticoagulants may be responsible intramural hematoma with an INR slightly increased or even normal [1]. Our patient presented without any context traumatic hematoma of the sigmoid mesocolon, associated with intraluminal hemorrhage, intramural and intraperitoneal responsible melaena, with hemoperitoneum, abdominal pain and hemodynamic instability. Oral anticoagulant therapy, although not overdosed, seems to be the cause.
The ground terminal chronic renal insufficiency presented our patient is not associated with coagulopathy, but may nevertheless be responsible for vascular fragility.
diagnosis based on ultrasound, CT and endoscopy [1]. The sonographic appearances of the hematoma are variable in time. Usually the fee is anechoic hematoma. Training and the gradual fragmentation of the clot explain the appearance of internal echoes and the existence of inconsistent type septal structures [5]. The CT appearance of the hematoma also varies over time. Recently, it appears spontaneously hyperdense, becoming isodense and then, finally, hypodense [4]. The management of the hematoma the sigmoid depends on the tolerance of the patient.
Conservative treatment includes aspiration digestive gastric tube in the presence of bowel obstruction, blood transfusion and correction of the state of hypocoagulability by administering low doses of vitamin K and fresh frozen plasma, while avoiding lead hypercoagulability may lead to thrombosis in patients with cardiovascular disease.
However, although most authors advocate conservative treatment in five of the 12 observations cited, surgery was necessary. The surgical approach was motivated by the rupture of the hematoma, abscess formation, abdominal pain and uncontrollable diagnostic uncertainty [1].
mesosigmoid The hematoma induced by anticoagulant during short is exceptional. Its diagnosis is based on ultrasonography and abdominal CT scan. Conservative treatment should be first-line setting. Surgical treatment is reserved for complicated shapes.
References
[1] Trompetas V, Yettimis E, Varsamidakis N, Courcoutsakis N, Kalokairinos E. Endoscopic diagnosis and conservative management of an intramural sigmoid haematoma complicating anticoagulant therapy. Acta Gastroenterol Belg 2007;70:313—5.
[2] Umeda I, Ohta H, Doi T, Nobuoka A, Kanisawa Y, Kawasaki R, et al. Idiopathic intramural hematoma of the colon. Gastrointest Endosc 2007;66:861—4.
[3] Hughes III CE, Conn J, Sherman JO. Intramural hematoma of the gastrointestinal tract. Am J Surg 1977;133:276—9.
[4] Abbas MA, Collins JM, Olden KW, Kelly KA. Spontaneous intramural small-bowel hematoma: clinical presentation and long-term outcome. Arch Surg 2002;137:306—10.
[5] Y Thery, Baumont R, Barkat F. Hematoma of the sigmoid mesocolon. About an exceptional case in Niger. J Radiol 1999; 80:312-6.
H. Chtata
Department of Cardiovascular Surgery, Military Hospital Mohamed V instruction, Rabat, Morocco
A. * Alahyane
Mr. Yaka
Service of Visceral Surgery, Military Hospital Mohamed V instruction, Rabat, Morocco Mr.
Oukabli
Pathology Service, Military Hospital Mohamed V instruction, Rabat , Morocco
Mr. Taberkant
A. Elkirrat
Department of Cardiovascular Surgery, Military Hospital Mohamed V instruction, Rabat, Morocco
* Corresponding author. 3 Department of Surgery, Hospital of Auxerre, 2, boulevard de Verdun, 89000 Auxerre Cedex, France.
E-mail: alahyanew@yahoo.fr
(A. Alahyane).
MSM, 43 years, chronic hemodialysis for five years, carrying a mechanical prosthetic mitral past three years and on long term anticoagulant therapy (Coumadin 4 mg / day) was admitted in March 2005 at the emergency department for pelvic pain lasting for a week, which had worsened, and generalized throughout the abdomen in a few hours with the appearance of syncope.
The examination revealed a state of shock with systolic blood pressure 70 mm Hg and a diastolic of 50 mmHg, profuse sweating, cold extremities and a significant mucocutaneous pallor. Abdominal palpation a tender mass in the left iliac fossa, ill-defined and mobile associated with distention and tenderness of the rest of the abdomen with dullness Slope.
The DRE revealed an melaena. Laboratory tests showed microcytic hypochromic anemia at 6 g / dl of hemoglobin and prothrombin time to 35% with an INR of 2.5. Abdominal ultrasound showed a peritoneal effusion of great abundance and a sigmoid wall thickening with anechoic halo périsigmoïdien.
urgent laparotomy was decided after a brief resuscitation and showed an abundance of hemoperitoneum and a hematoma of the sigmoid cracked and extended to the wall of the sigmoid (Fig. 1). Resection with double stoma was performed (Fig. 2). The postoperative course was uneventful. The restoration of gastrointestinal continuity was performed two months later. Examination histological part of colectomy showed the presence of a hemorrhagic collection at the mesocolon, which was leaking into the colonic subserosa, causing a detachment of the serosa. Elsewhere, there was a very congested in the mucosa and submucosa compared with no other associated injury, particularly vascular.
intramural hematomas can occur throughout the digestive tract. Trauma, hemophilia and anticoagulant therapy are the main causes. Cases of spontaneous hematomas were also reported
[2]. The most common are those located at of the small intestine and duodenum [3,4]. Hematoma of the colon and particularly those induced by anticoagulant therapy are very exceptional. Twelve cases are reported in the literature with only four locations sigmoid [1]. In association with bleeding and intraparietal intramésentérique may appear intraluminal bleeding, intra-or retroperitoneal [4].
abdominal pain and intestinal obstruction in general partial, are common symptoms. The INR is often increased beyond the therapeutic ranges. However, anticoagulants may be responsible intramural hematoma with an INR slightly increased or even normal [1]. Our patient presented without any context traumatic hematoma of the sigmoid mesocolon, associated with intraluminal hemorrhage, intramural and intraperitoneal responsible melaena, with hemoperitoneum, abdominal pain and hemodynamic instability. Oral anticoagulant therapy, although not overdosed, seems to be the cause.
The ground terminal chronic renal insufficiency presented our patient is not associated with coagulopathy, but may nevertheless be responsible for vascular fragility.
diagnosis based on ultrasound, CT and endoscopy [1]. The sonographic appearances of the hematoma are variable in time. Usually the fee is anechoic hematoma. Training and the gradual fragmentation of the clot explain the appearance of internal echoes and the existence of inconsistent type septal structures [5]. The CT appearance of the hematoma also varies over time. Recently, it appears spontaneously hyperdense, becoming isodense and then, finally, hypodense [4]. The management of the hematoma the sigmoid depends on the tolerance of the patient.
Conservative treatment includes aspiration digestive gastric tube in the presence of bowel obstruction, blood transfusion and correction of the state of hypocoagulability by administering low doses of vitamin K and fresh frozen plasma, while avoiding lead hypercoagulability may lead to thrombosis in patients with cardiovascular disease.
However, although most authors advocate conservative treatment in five of the 12 observations cited, surgery was necessary. The surgical approach was motivated by the rupture of the hematoma, abscess formation, abdominal pain and uncontrollable diagnostic uncertainty [1].
mesosigmoid The hematoma induced by anticoagulant during short is exceptional. Its diagnosis is based on ultrasonography and abdominal CT scan. Conservative treatment should be first-line setting. Surgical treatment is reserved for complicated shapes.
References
[1] Trompetas V, Yettimis E, Varsamidakis N, Courcoutsakis N, Kalokairinos E. Endoscopic diagnosis and conservative management of an intramural sigmoid haematoma complicating anticoagulant therapy. Acta Gastroenterol Belg 2007;70:313—5.
[2] Umeda I, Ohta H, Doi T, Nobuoka A, Kanisawa Y, Kawasaki R, et al. Idiopathic intramural hematoma of the colon. Gastrointest Endosc 2007;66:861—4.
[3] Hughes III CE, Conn J, Sherman JO. Intramural hematoma of the gastrointestinal tract. Am J Surg 1977;133:276—9.
[4] Abbas MA, Collins JM, Olden KW, Kelly KA. Spontaneous intramural small-bowel hematoma: clinical presentation and long-term outcome. Arch Surg 2002;137:306—10.
[5] Y Thery, Baumont R, Barkat F. Hematoma of the sigmoid mesocolon. About an exceptional case in Niger. J Radiol 1999; 80:312-6.
H. Chtata
Department of Cardiovascular Surgery, Military Hospital Mohamed V instruction, Rabat, Morocco
A. * Alahyane
Mr. Yaka
Service of Visceral Surgery, Military Hospital Mohamed V instruction, Rabat, Morocco Mr.
Oukabli
Pathology Service, Military Hospital Mohamed V instruction, Rabat , Morocco
Mr. Taberkant
A. Elkirrat
Department of Cardiovascular Surgery, Military Hospital Mohamed V instruction, Rabat, Morocco
* Corresponding author. 3 Department of Surgery, Hospital of Auxerre, 2, boulevard de Verdun, 89000 Auxerre Cedex, France.
E-mail: alahyanew@yahoo.fr
(A. Alahyane).
Monday, February 28, 2011
Chetna And Prithviraj
during aging: a concept of the past? A possible remedy
This might suggest that two recently published studies by teams at the Salk Institute for Biological Studies in La Jolla, California. Human aging remains now a poorly understood phenomenon and its study is complicated by the fact that this process stretches over a lifespan exceeding 80 years. Moreover, the very causes of aging are poorly known and many processes appear to be combined, at different levels, to contribute to this phenomenon. At the genetic level, telomeres appear to be the cause of aging in our DNA. At the protein level, accumulation of malformed proteins are the cause of death of certain cells. At the cellular level, oxidative stress associated with the activity of mitochondria is also a source of toxicity that is his due with age. At the macroscopic scale, environment and nutrition also play roles. The two studies conducted at the Salk Institute used to clarify some of these points.
A Spartan regime for longevity
Recently, studies have shown that it is possible to substantially increase the life span of certain animals and reduce their risk of age-related diseases (cancer , diabetes, cardiovascular diseases, etc..) reducing their daily nutritional intake, especially the amount of calories each day. The study of caloric restriction has shown that it was originally the activation of an enzyme called AMPK (AMP-activated protein kinase) present in many animal species. The action of this enzyme on the regulation of metabolism had already been studied in research on obesity [1] [2]. In the context of aging research, it was shown that reducing calorie activates AMPK, which then regulates the cellular activity to reduce their energy consumption. This slowdown is causing metabolic the increase in life span observed, but the process initiated by AMPK and biomolecules with which it interacts in this hitherto unknown mechanism. A team led by Andrew Dillin and Reuben Shaw studied at Ceanorhabditis elegans (a worm used as a model), possible targets of AMPK [3].
By studying the genome of the worm, they found a likely target: a protein called CRTC1 (CREB-regulated transcription coactivator 1). By inhibiting the production of CRTC1 in Ceanorhabditis elegans, researchers have observed an increase of 40% of its useful life. The team subsequently confirmed the link between AMPK and CRTC1 showing that the first second inactive in catalyzing the phosphorylation of the second. The addition of a phosphate group on a site specific CRTC1 off because this protein. The key role of CRTC1 in the process has also been confirmed by studying its interaction with another enzyme called calcineurin, which plays the opposite role of AMPK and removes the phosphate group that disables CRTC1. In summary, CRTC1 can be compared to a switch of aging, which can be ignited by either calcineurin or extinguished by AMPK. In addition, the site of phosphorylation of key CRTC1 is widely retained within the animal kingdom.
The combination of these two properties makes this protein an excellent target for the development of a pharmaceutical treatment. By developing a compound that inhibits directly CRTC1, researchers hope to reach replicate the beneficial effects of calorie restriction on longevity, while avoiding its greatest flaw: the fact of having to maintain a state of perpetual hunger.
study the pathologies of aging to better understand the phenomenon
Meanwhile, another team from the Salk Institute, led by Juan-Carlos Izpisua Belmonte has focused on the study of human disease very rare and currently incurable syndrome called Hutchinson-Gilford (progeria or) to understand the mechanisms linked to cellular aging. This disease is indeed characterized by accelerated aging of the human being, who is showing signs of senescence at the age of two years. Children with this disease are very rare (64 cases listed in the world today) and usually die from vascular disease before the age of 13. This disease is caused by a single mutation of the gene encoding lamin A, a protein that plays a critical role in organizing the cell nucleus. The mutation causes the synthesis of a shortened version of the lamin A, progerin called, which therefore plays more role in structuring the kernel, therefore causing many problems on the genetic activity of the cell. The cells are then very quickly look "old" characterized by a malformed nucleus and DNA folded incorrectly.
Dr. Belmonte's team has created a line of induced pluripotent stem cells from fibroblasts (skin cells) from patients with progeria. Their goal is to use stem cells to create different types of differentiated cells and observe the effects of accelerated aging in each of these lineages. It is thus possible to observe in the space of two weeks of the phenomena that take several decades for most people. However, it could suggest that stem cell line obtained is also subjected to accelerated aging. The fact that this is not the case constitutes an achievement in itself and an additional study showed that lamin A / progerin was not synthesized in stem cells but only in cells differentiated. Once these stem cells are differentiated, the synthesis of progerin cell begins and symptoms of progeria occur again.
The stem cell line obtained not only to study the effects of aging in different cell types but also some other action of progerin. The team of Dr. Belmonte has shown that progerin accumulates and form clusters, mainly in the smooth muscle cells lining the arterial blood vessels. Clusters cause degeneration of these cells, causing vascular disease often fatal for people with progeria. The accumulation of protein in these cells could be a biomarker of interest for monitoring of physiological aging.
Finally, researchers have shown that it is possible to prevent the appearance of accelerated aging in genetically modifying the stem cells induced to inhibit the synthesis of progerin. This could be a trail of treatment for progeria. In all cases, obtaining this new cell line is an interesting development for the study of aging. The study was published in the journal Nature [4].
These two studies show the complexity and variety of phenomena associated with aging. Demographic trends observed across the world make the study of aging, a subject of great importance in the field of biology.
For more information, contact:
- [3] Article (in English, subscription required to access the full text):
http://www.nature.com/nature/journal/v470 / n7334/full/nature09706.html
- [4] Article (in English, subscription required to access the full text) :
http://redirectix.bulletins-electroniques.com/x0bok
- The Salk Institute (in English): http://www.salk.edu/
Source:
- [1] discovered in mice a drug that "burn" fat, Alexander Touvat, Bulletin U.S. 195,
http://www.bulletins-electroniques.com/actualites/62275.htm
- [2] The woodchuck model of human obesity research, Alexander Touvat, Bulletin U.S. 214, http://www.bulletins-electroniques.com/actualites/63881.htm
- Hungering for Longevity - Salk Scientists Identify The confluence of aging signals, The Salk Institute for Biological Studies, February 17, 2011, http://www.salk.edu/news/pressrelease_details.php?press_id=472
- Aging, interrupted, The Salk Institute for Biological Studies, February 23, 2011, http://www.salk.edu/news/pressrelease_details.php?press_id=473 
This might suggest that two recently published studies by teams at the Salk Institute for Biological Studies in La Jolla, California. Human aging remains now a poorly understood phenomenon and its study is complicated by the fact that this process stretches over a lifespan exceeding 80 years. Moreover, the very causes of aging are poorly known and many processes appear to be combined, at different levels, to contribute to this phenomenon. At the genetic level, telomeres appear to be the cause of aging in our DNA. At the protein level, accumulation of malformed proteins are the cause of death of certain cells. At the cellular level, oxidative stress associated with the activity of mitochondria is also a source of toxicity that is his due with age. At the macroscopic scale, environment and nutrition also play roles. The two studies conducted at the Salk Institute used to clarify some of these points.
A Spartan regime for longevity
Recently, studies have shown that it is possible to substantially increase the life span of certain animals and reduce their risk of age-related diseases (cancer , diabetes, cardiovascular diseases, etc..) reducing their daily nutritional intake, especially the amount of calories each day. The study of caloric restriction has shown that it was originally the activation of an enzyme called AMPK (AMP-activated protein kinase) present in many animal species. The action of this enzyme on the regulation of metabolism had already been studied in research on obesity [1] [2]. In the context of aging research, it was shown that reducing calorie activates AMPK, which then regulates the cellular activity to reduce their energy consumption. This slowdown is causing metabolic the increase in life span observed, but the process initiated by AMPK and biomolecules with which it interacts in this hitherto unknown mechanism. A team led by Andrew Dillin and Reuben Shaw studied at Ceanorhabditis elegans (a worm used as a model), possible targets of AMPK [3].
By studying the genome of the worm, they found a likely target: a protein called CRTC1 (CREB-regulated transcription coactivator 1). By inhibiting the production of CRTC1 in Ceanorhabditis elegans, researchers have observed an increase of 40% of its useful life. The team subsequently confirmed the link between AMPK and CRTC1 showing that the first second inactive in catalyzing the phosphorylation of the second. The addition of a phosphate group on a site specific CRTC1 off because this protein. The key role of CRTC1 in the process has also been confirmed by studying its interaction with another enzyme called calcineurin, which plays the opposite role of AMPK and removes the phosphate group that disables CRTC1. In summary, CRTC1 can be compared to a switch of aging, which can be ignited by either calcineurin or extinguished by AMPK. In addition, the site of phosphorylation of key CRTC1 is widely retained within the animal kingdom.
The combination of these two properties makes this protein an excellent target for the development of a pharmaceutical treatment. By developing a compound that inhibits directly CRTC1, researchers hope to reach replicate the beneficial effects of calorie restriction on longevity, while avoiding its greatest flaw: the fact of having to maintain a state of perpetual hunger.
study the pathologies of aging to better understand the phenomenon
Meanwhile, another team from the Salk Institute, led by Juan-Carlos Izpisua Belmonte has focused on the study of human disease very rare and currently incurable syndrome called Hutchinson-Gilford (progeria or) to understand the mechanisms linked to cellular aging. This disease is indeed characterized by accelerated aging of the human being, who is showing signs of senescence at the age of two years. Children with this disease are very rare (64 cases listed in the world today) and usually die from vascular disease before the age of 13. This disease is caused by a single mutation of the gene encoding lamin A, a protein that plays a critical role in organizing the cell nucleus. The mutation causes the synthesis of a shortened version of the lamin A, progerin called, which therefore plays more role in structuring the kernel, therefore causing many problems on the genetic activity of the cell. The cells are then very quickly look "old" characterized by a malformed nucleus and DNA folded incorrectly.
Dr. Belmonte's team has created a line of induced pluripotent stem cells from fibroblasts (skin cells) from patients with progeria. Their goal is to use stem cells to create different types of differentiated cells and observe the effects of accelerated aging in each of these lineages. It is thus possible to observe in the space of two weeks of the phenomena that take several decades for most people. However, it could suggest that stem cell line obtained is also subjected to accelerated aging. The fact that this is not the case constitutes an achievement in itself and an additional study showed that lamin A / progerin was not synthesized in stem cells but only in cells differentiated. Once these stem cells are differentiated, the synthesis of progerin cell begins and symptoms of progeria occur again.
The stem cell line obtained not only to study the effects of aging in different cell types but also some other action of progerin. The team of Dr. Belmonte has shown that progerin accumulates and form clusters, mainly in the smooth muscle cells lining the arterial blood vessels. Clusters cause degeneration of these cells, causing vascular disease often fatal for people with progeria. The accumulation of protein in these cells could be a biomarker of interest for monitoring of physiological aging.
Finally, researchers have shown that it is possible to prevent the appearance of accelerated aging in genetically modifying the stem cells induced to inhibit the synthesis of progerin. This could be a trail of treatment for progeria. In all cases, obtaining this new cell line is an interesting development for the study of aging. The study was published in the journal Nature [4].
These two studies show the complexity and variety of phenomena associated with aging. Demographic trends observed across the world make the study of aging, a subject of great importance in the field of biology.
For more information, contact:
- [3] Article (in English, subscription required to access the full text):
http://www.nature.com/nature/journal/v470 / n7334/full/nature09706.html
- [4] Article (in English, subscription required to access the full text) :
http://redirectix.bulletins-electroniques.com/x0bok
- The Salk Institute (in English): http://www.salk.edu/
Source:
- [1] discovered in mice a drug that "burn" fat, Alexander Touvat, Bulletin U.S. 195,
http://www.bulletins-electroniques.com/actualites/62275.htm
- [2] The woodchuck model of human obesity research, Alexander Touvat, Bulletin U.S. 214, http://www.bulletins-electroniques.com/actualites/63881.htm
- Hungering for Longevity - Salk Scientists Identify The confluence of aging signals, The Salk Institute for Biological Studies, February 17, 2011, http://www.salk.edu/news/pressrelease_details.php?press_id=472
- Aging, interrupted, The Salk Institute for Biological Studies, February 23, 2011, http://www.salk.edu/news/pressrelease_details.php?press_id=473
Example Of 4187 Curtailment
Coupe de France finals of the 16th Coupe de France: it went very well but this has not gone ...
designated shooters during training last Thursday night and the two guards Stadium occur at midfield, immediately get together and huddle in a circle. Their partners are aligned and hug the edge of the button forming one. Under the command of the arbitrators enchainent penalty shootout. At each penalty scored our supporters burst of joy and echo their horns and drums. Every penalty conceded they express their intense disappointment. We perform a series perfect for shooting with five successes, without trembling. Unfortunately, our opponents are also very effective and the suspense becomes unbearable because pervasive and intensifying over an hour. Equal 5 all after the first round. We must continue with this time of sudden death. An exploit the goalkeeper on our sixth attempt, then without shaking the shooter HB3V crucify Alex, sprints to his partners and they all celebrate. From our side, after a few seconds of relief and huge disappointment we get together and exchange a few words to thank our great friends even more fans disappointed but we hiding for some very worthy few tears while testifying in blood meeting and the disappointment of all. 
In 
analysis of the game hurts. We are not able to handle the event. We are never truly back in the match and did not play our game Confirmation that the mental dimension and experience in these meetings are crucial. Technically, we have once again been ineffective and too often what passes in the league in the Landes, does not forgive this kind of meeting. Some significant figures: 
This adventure in France was cut very nice and ends with a superb weekend in Limousin, which starts Saturday morning with a start in a bus full (players, managers, supporters, hopes, dreams, desires ... ). After a trip without incident, we arrive at the cottage booked for several weeks. We can say that the choice is excellent as the setting and amenities are first class. The end of the day begins before the rugby team in France, continues with a dinner hosted and ends an evening more or less sage according to individual choice and enjoyable for all. After a short night and a breakfast, refreshing for some, we went to the room focused players, fans made up and fitted with yellow and black ready to set the mood. Too bad the day Sunday was shorter than planned because we had all the desire and motivation so that it lasts until very late. Despite the disappointment, the return was cheerful and courageous ended the day with a last meal together at the clubhouse at Silver. 
designated shooters during training last Thursday night and the two guards Stadium occur at midfield, immediately get together and huddle in a circle. Their partners are aligned and hug the edge of the button forming one. Under the command of the arbitrators enchainent penalty shootout. At each penalty scored our supporters burst of joy and echo their horns and drums. Every penalty conceded they express their intense disappointment. We perform a series perfect for shooting with five successes, without trembling. Unfortunately, our opponents are also very effective and the suspense becomes unbearable because pervasive and intensifying over an hour. Equal 5 all after the first round. We must continue with this time of sudden death. An exploit the goalkeeper on our sixth attempt, then without shaking the shooter HB3V crucify Alex, sprints to his partners and they all celebrate. From our side, after a few seconds of relief and huge disappointment we get together and exchange a few words to thank our great friends even more fans disappointed but we hiding for some very worthy few tears while testifying in blood meeting and the disappointment of all. 
An hour before the two young referees give the kick-off meeting in the beautiful hall of the complex of Saint Irieix perch (87). Both teams are very motivated (we would be at least) are clenched. The prohibition on the use of glue to help, many blunders are committed. At this game, players are faring in the Dordogne a little better and get the best start to lead 3-1. The game is weird, our players do not play. The impression they have stepped on the brake. The defense is present only intermittently, our mounted ball played in slow motion. We can not keep up with our opponents who remain in the lead but did not widen the gap that is keeping 1 or 2 goals. Our attack only found few solutions for lack of speed and commitment. Contacts with the opposing defense is very tough, sometimes to the limit. One or both would, in my view, have been punished more severely. Half-time is achieved with a score of 10 to 9 in our favor. One would think that the break would release our players. Unfortunately this was not the case and the beginning of the second act is identical to the first halftime ...
worse, since we allow players to Dordogne take up to 4 units in advance to lead 17-13. That's when we wake up a bit and with some nice action and found a defense, we go back and equate to 17 everywhere. Our opponents react and stop the bleeding by taking a goal lead. After a few misfires on both sides, we equalize. A good defense and the next attack we take the advantage 19-18. Taking advantage of numerical superiority we recover the ball at 50 seconds of the final whistle. Symbol of this match we were never able to master it, after about fifteen seconds into the attack, the referee raise his arm signifying that we had to shoot quickly. Our shooting precipitate is stopped by the goalkeeper. On the attack last chance, the players of Bergerac yet outnumbered manage to equalize. 19 across the final whistle and it is directly the shootout goals.
analysis of the game hurts. We are not able to handle the event. We are never truly back in the match and did not play our game Confirmation that the mental dimension and experience in these meetings are crucial. Technically, we have once again been ineffective and too often what passes in the league in the Landes, does not forgive this kind of meeting. Some significant figures: Only 54% of success in shooting, we scored more goals than our opponents have made 10 more shots, a low percentage of success at the wing (30%), 10 turnovers unprovoked ... It's hard to hear but true and this book should serve to the end of the season and help us achieve our main objective.
This adventure in France was cut very nice and ends with a superb weekend in Limousin, which starts Saturday morning with a start in a bus full (players, managers, supporters, hopes, dreams, desires ... ). After a trip without incident, we arrive at the cottage booked for several weeks. We can say that the choice is excellent as the setting and amenities are first class. The end of the day begins before the rugby team in France, continues with a dinner hosted and ends an evening more or less sage according to individual choice and enjoyable for all. After a short night and a breakfast, refreshing for some, we went to the room focused players, fans made up and fitted with yellow and black ready to set the mood. Too bad the day Sunday was shorter than planned because we had all the desire and motivation so that it lasts until very late. Despite the disappointment, the return was cheerful and courageous ended the day with a last meal together at the clubhouse at Silver.
A big thank you to all and all for this weekend.
Thanks to all the people who donate their time, sometimes with their money, we lived together at times like these. Thank you fans who supported us and those who could not be physically present there but all other times. Players and staff are aware of everything you do for them and thank you. Thanks to all the Stade Montois Hand Ball is a club where we feel good.
Landais Thanks also to the clubs (they will recognize themselves) for their messages of support.
Finally thank you to Cup in France, a competition in this new format allows all clubs and players to dream Handball and live the good times.
To relive those days, go through the link to the photos already online.
Saturday, February 26, 2011
Causes For High Hematocrit In Dachshunds
senior senior senior
team Senior B moves Mt St Sulpice for 13h
appointment stage at 11:45
appointment stage at 11:45
Senior A team moves for 15h at Varennes
appointment stadium 14h
appointment stadium 14h
Wednesday, February 23, 2011
Homemade Sausage Stufferplans
The adventure ...
September 18, 2010 ...
LONS: this past
--------------- -------------------------------------------------- ------------------------ October 31, 2010 ...
VILLENAVE OF ORNON it went
----- -------------------------------------------------- --------------------------------
November 27, 2010 ...
MEDOC is past
------------------ -------------------------------------------------- ------------------- December 18, 2010 ...
MONSEGUR it went
----------------------------- -------------------------------------------------- -------- January 9, 2011 ...
SARLAT it went
---------- -------------------------------------------------- ----------------------------- February 27, 2011 ...
is for us to write the next adventure ....
Subscribe to:
Posts (Atom)